Brazil recorded 1,269 additional COVID-19 deaths on Wednesday, bringing its official death toll from the novel coronavirus to 46,510, the most in the world outside the United States.

Roche’s rheumatoid arthritis drug Actemra failed to help patients with early-stage COVID-19 pneumonia in an Italian study, the latest instance in which an anti-inflammatory drug has fallen through in a coronavirus trial.

The World Health Organization hopes hundreds of millions of doses of coronavirus vaccine can be produced this year and 2 billion doses by the end of 2021 and is drawing up plans to help decide who should get the first doses once a vaccine is approved, its chief scientist said.

Just days before U.S. President Donald Trump’s campaign rally in Tulsa, the biggest event in the country since pandemic restrictions were imposed in March, new coronavirus cases are surging in Oklahoma, Texas, Arizona and elsewhere.

Turkey on Thursday made it compulsory for people to wear face masks when outside in the country’s largest cities of Istanbul and Ankara, as well as the northwestern city of Bursa, in a bid to combat the spread of the coronavirus.

Roche Holding AG’s Actemra did not improve symptoms in patients with early-stage COVID-19 pneumonia, scientists conducting a study of the drug in Italy said on Wednesday, raising questions about the potential of the Swiss drugmakers’ rheumatoid arthritis drug to treat the novel coronavirus.

Proposed changes to requirements that state-run Medicaid programs are given the best drug prices would clear the way for commercial health insurers to enter into “value-based” payment schemes, the U.S. Centers for Medicare & Medicaid Services said on Wednesday.

Drugmaker Gilead Sciences said on Wednesday it will soon begin enrollment of pediatric patients with moderate-to-severe COVID-19 in a late-stage study testing its experimental drug, remdesivir.

Just days before U.S. President Donald Trump’s campaign rally in Tulsa, the biggest event in the country since pandemic restrictions were imposed in March, new coronavirus cases are surging in Oklahoma, Arizona and other states.

The following is a brief roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.